Role of lubricin and boundary lubrication in the


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Conformational Mechanics, Adsorption, and Normal Force ....

Glycoproteins, such as lubricin, and hyaluronic acid (HA) play a prominent role in the boundary lubrication mechanism in diarthrodial joints. Although many studies have tried to elucidate the lubrication mechanisms of articular cartilage, the molecular details of how lubricin and HA interact with cartilage surfaces and mediate their interaction still remain poorly understood.

The role of lubricin in normal and pathological joint ....

of lubricin, including lubrication and cytoprotection. Lubricin plays an important role in articular joint physiology, and the loss of accumu-lation of lubricin may be a factor in the pathology of osteoarthritis (OA) (Figure 1). Therefore, a recent study8 demonstrated that recombi-nant lubricin has a role in chondro-protection in an animal OA model

Role of lubricin and boundary lubrication in the ....

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Article in Proceedings of the National Academy of Sciences 110(15) · March 2013 with 30 Reads

Proteoglycan 4 - Wikiped...

Function. Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis.When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Lubricin, MSF, and SZP are now collectively known as Proteoglycan 4 (hence PRG4 for the gene nomenclature).

Regulation of lubricin for functional cartilage tissue ....

Structure and functional role of lubricin. Lubricin, a product of the proteoglycan 4 (PRG4) gene, is highly expressed by synoviocytes and superficial zone chondrocytes [].Lubricin, generally known as a proteoglycan, is a glycoprotein that functions as a critical boundary lubricant for articular cartilage and normally isolated from synovial fluid [].

The role of lubricin in the mechanical behavior of ....

The role of lubricin in the mechanical behavior of synovial fluid. Jay G.D., Torres J.R., Warman M.L., Laderer M.C., Breuer K.S. Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA-protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load.

Role of lubricin and boundary lubrication in the ....

Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage in the presence of altered joint mechanics and chondrocyte death, but the connection between these factors is not well established. Lubricin, a mucinous glycoprotein encoded by the PRG4 gene, provides boundary lubrication in articular joints. Joint friction is elevated and accompanied by accelerated ...

The role of lubricin in normal and pathological joint tissue: a contemporary revi...

The aim of this article was to critically review the literature about lubricin and its involvement in normal and pathological joint tissue. In particular, our research focussed on new therapeutic approaches for the treatment of osteoarthritis related to lubricin. We reviewed the literature regarding lubricin expression.

Lubricants | Free Full-Text | Advances in Tribology of ....

The boundary lubrication of the surfaces has also been studied, and the role of lubricin and HA (polyelectrolyte) during the initiation and progression and later stages of wear has been investigated in their experiments.

Lubricin - Brown Universi...

provides lubrication but does not prevent wear, enabling a pencil to leave a residue (writing). Lubricin lubricates via the boundary mode which is a regime in the leftward area of the Striebek curve (Márton & Lantos, 2006). This means that boundary lubrication functions independently of synovial fluid viscosity.

Cartilage boundary lubrication synergism is ... - SpringerLi...

Background. Proteoglycan 4 (PRG4) and hyaluronan (HA) are key synovial fluid constituents that contribute synergistically to cartilage boundary lubrication; however, the effects of their concentrations as well as their structure, both of which can be altered in osteoarthritis, on this functional synergism are unknown.

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Kimberly A. Wallera, Ling X. Zhangb, Khaled A. Elsaidc, Braden C. Fleminga,d,e, Matthew L. Warmanf,g, and Gregory D. Jaya,b,h,1 aCenter for Biomedical Engineering and the School of Engineering, Brown University, Providence, RI 02912; bEmergency Medicine Research Laboratory, Department of Emergency Medicine ...

Anti-Inflammatory Role of Lubricin/Proteoglycan 4 (PRG4 ....

Background/Purpose: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblast and superficial zone chondrocyte. PRG4 has a homeostatic multifaceted role in the joint including boundary lubrication, friction lowering of apposed cartilage surfaces and prevention of synovial overgrowth. PRG4 is abundant in the synovial fluid (SF) and its levels are reduced in SF ...

Proteoglycan 4 - Wikiped...

Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis.When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Lubricin, MSF, and SZP are now collectively known as Proteoglycan 4 (hence PRG4 for the gene nomenclature).

Boundary mode lubrication of articular cartilage by ....

Lubrication of cartilage involves a variety of physical and chemical factors, including lubricin, a synovial glycoprotein that has been shown to be a boundary lubricant. It is unclear how lubricin boundary lubricates a wide range of bearings from tissue to artificial surfaces, and if the mechanism is the same for both soluble and bound lubricin.

Regulation of lubricin for functional cartilage tissue ....

Structure and functional role of lubricin. Lubricin, a product of the proteoglycan 4 (PRG4) gene, is highly expressed by synoviocytes and superficial zone chondrocytes [].Lubricin, generally known as a proteoglycan, is a glycoprotein that functions as a critical boundary lubricant for articular cartilage and normally isolated from synovial fluid [].

Role of lubricin and boundary lubrication in the ....

Title: Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis: Authors: Waller, K. A.; Zhang, L. X.; Elsaid, K. A.; Fleming, B. C ...

The role of lubricin in the mechanical behavior of ....

Download Citation on ResearchGate | The role of lubricin in the mechanical behavior of synovial fluid | Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which ...

Galectin-3 Binds to Lubricin and Reinforces the ....

Effective boundary lubrication by lubricin is dependent upon both its ability to adsorb to articular cartilage 11,12 and the presence of O-linked β(1–3)Gal-GalNAc oligosaccharides 13; however ...